The ABC medical drama first premiered March 27, 2005.
Ten years, 11 seasons, and countless medical traumas, death scares, bomb threats, plane crashes, near-drownings, gunmen, weddings, babies, tears, and hospital hook-ups ago, we checked into Seattle Grace. Today, March 27, is the official 10-year anniversary of Grey’s Anatomy.
Here are the only five original characters still on the show in 2005 and now:
Ellen Pompeo as Meredith Grey
Patrick Dempsey as Derek Shepherd
Justin Chambers as Alex Karev
Chandra Wilson as Miranda Bailey
James Pickens Jr. as Richard Webber
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The rest of the original cast have left since Grey’s for other opportunities:
Sandra Oh as Cristina Yang
Oh left Grey Sloan Memorial Hospital after season 10 in 2014 and has since appeared in Melissa McCarthy’s maligned comedy Tammy.
Katherine Heigl as Izzie Stevens
Heigl left during the sixth season to make a handful of bad rom-coms and now stars as CIA analyst Charlie Tucker on State of Affairs.
T.R. Knight as George O’Malley
Knight was killed off at the end of season five and has since done a guest arc on The Good Wife and starred in the failed Amazon pilot, Hysterical.
Isaiah Washington as Preston Burke
Washington was fired in season three -- though he did return for an episode in the 10th season -- and now plays Chancellor Thelonious Jaha on The 100.
Find out why the Grey’s Anatomy actors would be horrible doctors in real life: