Michael Weatherly Is Leaving 'NCIS' After 13 Seasons: 'It's Been a Fantastic Ride'

Goodbye, DiNozzo.

Actor Michael Weatherly took to Twitter on Tuesday to reveal that his time on NCIS is coming to an end.

"DiNozzo is a wonderful, quixotic character & I couldn't have had more fun playing him over the past 13 seasons," he tweeted, along with a selfie on the NCIS set he’s called home for over a decade.

WATCH: Jon Cryer Accomplishes His TV Dream of Guest Starring on 'NCIS'

"Les Moonves & CBS gave me the opportunity of a lifetime," the 47-year-old actor continued in another tweet, accompanied by a photo of him with co-star Pauley Perrette.

"I will miss the amazing crew & cast, who are like family to me, & to the fans all over the world - THANK YOU, it’s been a fantastic ride!" he closed out his announcement.

WATCH: Why 'NCIS' is the No. 1 Show in the World

Weatherly has been a fan favorite on the popular CBS crime procedural since its inception in 2003. In 2014, Weatherly talked to ET about how the long-running series -- which spawned spinoffs NCIS: LA and NCIS: New Orleans -- has attained global popularity over the years.

"[People around the world] love the humor and the interaction between the characters," Weatherly said at the time. "It feels like a family, and it feels real. Or it feels like their work place… we don't just solve a crime, we fill in all that other stuff."

"This show has had to change over and over and over again," he added. "And that is really where the extraordinary value is."

Meanwhile, Weatherly's on-screen love interest, Ziva, was played by Cote De Pablo, who left the show to much fanfare in 2014. Could De Pablo return to see Weatherly off?

Watch the video below to see Weatherly talk about how NCIS meant so much to so many people.