Meanwhile, Lamar Odom remains in critical condition in a Nevada hospital.
Scott Disick has checked into a drug and alcohol rehab center for treatment, a source confirms to ET.
The news breaks one day after the Keeping Up With the Kardashians star shared a cryptic message on his Instagram account, posting an image with the phrase "Never give up" written in chalk, but no additional caption.
WATCH: Scott Disick Shares Cryptic Post: 'Never Give Up'
The 32-year-old has been having a tough year, as he and longtime love Kourtney Kardashian called it quits in July after Disick was photographed cozying up to an ex-girlfriend in Monte Carlo. "I made the worst decision I've ever made in my life," Disick told Kardashian in a recent episode of the family's reality series.
Together, Kardashian and Disick share three young children, but a source recently told ET not to expect a rekindled romance anytime soon.
"Kourtney is not taking Scott back -- never, as of right now," the source said. "Kourtney has been through a lot of drama with Scott over the years but it's for real this time."
Just this month, Disick was seen out and about with his rumored new girlfriend, 18-year-old model Lindsay Vrckovnik.
WATCH: Kourtney Kardashian Reacts to Scott Disick's 18-Year-Old Model Girlfriend
Meanwhile, Khloe Kardashian has been keeping vigil by her estranged husband's bedside. Lamar Odom is in critical condition after being found unresponsive at the Love Ranch brothel in Crystal, Nevada, on Tuesday. A source tells ET that the former NBA star suffered a heart attack and was placed into a medically induced coma.
While Odom's condition has improved, our source says "it is still dire."
By Khloe's side during this difficult time is her sister, Kim Kardashian, and mother, Kris Jenner. ET has confirmed that cameras are not currently rolling for KUWTK.
Get the latest on Odom's condition in the video below.