Sandra Bullock Talks Jesse James Affair in 'Vogue'

Sandra Bullock, 49, dazzles on the October cover of Vogue in a stunning backless Marc Jacobs gown, and in the brand-new interview, she reflects back on the explosive Jesse James cheating scandal which resulted in the demise of their five-year marriage.

"We're all where we're supposed to be," she says now about the situation. "I am exactly where I want to be now. You can't go backward. I'm not going backward."

Pics: Sandra and Her Adorable Son Louis

She clearly feels grateful for her present-day situation, which involves raising her son Louis as a single parent.

"I'm grateful that I'm here, blessed to have what I have. Nobody can be prepared for anything," she reflects. "If you end up in a place where you can look back and go, 'It happened, but I'm so lucky to be sitting where I am sitting ... '"

In the new interview, she reveals the great lengths she will go to protect Louis -- even if it means quitting acting.

"I think this business can take the child out of kids so quickly," she explains. "I don't want him to have pressures brought on by what I do. I will quit. I will leave. If I see whatever I'm doing affecting him negatively, I will pack up and move to Alaska."

Bullock's famous friends also weigh in on what makes Bullock one of the most likeable actresses in Hollywood, and according to her Gravity co-star George Clooney, it's her relatability.

"There has always been a really levelheaded, smart, funny girl you feel like you know," he says. "[It's] as if she [Bullock] was the cool girl next to you in school."

Related: Sandra Bullock Defies 'Gravity'

Her Heat co-star Melissa McCarthy echoes the sentiment.

"It's as if she has no idea that she's one of the most famous people on the planet," McCarthy says. "She's just solidly who she is. I don't know what she thinks, but she's never getting rid of me."