The 'If I Could Turn Back Time' singer was also to be an executive producer on the forthcoming project.
Cher will no longer appear in the Lifetime movie about the 2016 water crisis in Flint, Michigan.
The "If I Could Turn Back Time" singer revealed in a statement on Friday that she'd no longer be able to meet her commitment to the forthcoming project, citing a "serious family issue."
"This has been a project so near and dear to my heart and I was truly looking forward to helping tell this story," the 70-year-old actress told ET in a statement via her rep. "Unfortunately, I will be unable to leave Los Angeles during the scheduled filming as I am dealing with a serious family issue that prevents me from going on location for the April filming."
"I’m so glad that Craig and Neil [the producers] plan to move ahead and I know that this Lifetime movie will be done beautifully," Cher added.
Cher, who has donated water bottles to the Flint community, was also to be an executive producer on the TV movie, which would have marked her first return to the small screen since her Golden Globe-nominated role in If These Walls Could Talk.
READ: Beyonce Helps Raise $82,000 for Flint Water Crisis Ahead of Formation Tour Stop in Detroit
THR first reported that Cher had dropped out of the project.
The singer also has two shows scheduled in National Harbor, Maryland, this weekend. ET has reached out to AEG to see if those performances will be canceled.
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