Oprah Winfrey on her 'Biggest Mistake'

Believe it or not, Oprah Winfrey makes mistakes!

Sitting down for a candid interview with Christina McLarty, the queen of talk shares what she feels is her biggest regret in her 25-year run on The Oprah Winfrey Show.

MORE: Backstage at Oprah Winfrey's 'Surprise Spectacular' Show

In the very first episode of Oprah's newest venture Lifeclass, premiering Monday on OWN, Winfrey will resume the teacher/life coach role, imparting invaluable lessons to viewers gleaned from her time spent hosting the iconic talk show.

When asked about the infamous "wagon of fat" which will be highlighted in the very first episode of Lifeclass, Oprah rolls her eyes dramatically at the memory. "When I look at that show, I think it was one of the biggest ego trips of my life," Oprah explains. "When I look back at that, I think 'mistake' in many ways."

MORE: Lady Gaga Tops Oprah In Forbes Powerful Women

Reflecting on what she could have done differently, Oprah says she would've told herself "'DON'T DO IT!' It's a great TV moment, but don't do it."

MORE: Rosie O'Donnell Dishes on Sealing Her TV Deal with Oprah Winfrey

Oprah's Lifeclass debuts on OWN on Monday, October 10. Watch the video to see what makes Oprah angry -- and what her guilty pleasure is!