The 'America's Got Talent' host announced the unfortunate news via Instagram on Thursday.
Feel better, Nick Cannon!
The America's Got Talent host took to Instagram on Thursday to inform his fans that he'll be spending Christmas at Cedars-Sinai Medical Center in Los Angeles due to complications from lupus.
WATCH: Nick Cannon Talks Holiday Plans With Mariah Carey
"For all who have been trying to contact me the last few days this is where I've been," he captioned a pic taken straight from his hospital bed. "And I will be in the Hospital through Christmas. All good though, Doctors say I will be back to normal before the New Year. #LupusSucks #ncredible #warrior."
Unfortunately, this isn't the first time Cannon, who revealed he was diagnosed with the autoimmune disease in March 2012, has had to deal with medical issues during the holidays. The 36-year-old comedian first experienced kidney problems in December 2011 when he was vacationing in Aspen, Colorado, with his family.
"Currently being transferred to a hospital in LA," Cannon tweeted at the time. "Thank you all for all your love, prayers and concern. You know me… I will be a'ight."
RELATED: Nick Cannon Reveals He Has Lupus
ET caught up with Cannon earlier this month at the Critics' Choice Awards in Los Angeles, where he couldn't stop gushing about reuniting with his ex-wife, Mariah Carey, and their 5-year-old twins, Monroe and Moroccan, for the holidays.
"All fun, all love, you know what it is!" he said. "Holidays are mainly for kids anyway, when you think about it, and once you go from kids, it's all about family and love and that's what we're trying to spread."
Although Cannon will be absent from this year's festivities, that's not stopping Carey from having some fun! The "All I Want for Christmas" singer is currently staying in a cozy five-bedroom, five-bathroom cabin in Aspen with her kids, as well as her new boyfriend, backup dancer Bryan Tanaka.
Carey's pad for the holidays, courtesy of Airbnb, includes two living rooms, a wood-burning fireplace, gym, sauna, hot tub, wine room and breathtaking views of the surrounding snowy mountains.
WATCH: Inside Mariah Carey and Boyfriend Bryan Tanaka's 'Romantic' Aspen Getaway
"[Mariah and Bryan] walk around holding each other's hands and are always very affectionate. [They're] always smooching," an eyewitness told ET on Tuesday. "They get along great and like to cuddle."
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