The tennis pro is joined in the calendar by Amy Schumer, Ava DuVernay, Yoko Ono and Patti Smith.
Whatever month Serena Williams ends up posing for, it'll surely be sexy.
The 33-year-old tennis pro stripped down for the 2016 Pirelli Calendar, shot by renowned photographer Annie Leibovitz.
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Trainwreck star Amy Schumer, Selma director Ava DuVernay, Just Kids author Patti Smith and Yoko Ono are also among this year's handpicked models!
For the calendar's 43rd year, Leibovitz revealed that she wanted to take a different approach. "This calendar is so completely different. It is a departure," she said in a statement. "The idea was not to have any pretense in these pictures and be very straightforward."
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Leibovitz shared the inspiration behind the 2016 portraits.
"I started to think about the roles that women play, women who have achieved something. I wanted to make a classic set of portraits." she said. "I thought that the women should look strong but natural and I decided to keep it a very simple exercise of shooting in the studio."
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The 2016 calendar will be officially presented at the Roundhouse in London on November 30, 2015.
Williams is becoming quite the cover girl, but let's flashback to 2000 when she shared with ET her secrets to winning the U.S. Open.