The 'Grey's Anatomy' star and wife Jillian Fink have been married for 15 years.
Looks like McDreamy is back on the market.
Grey’s Anatomy star Patrick Dempsey and his wife of 15 years, Jillian Fink, are divorcing, ET can confirm.
WATCH: The Most Surprising Celebrities Splits of 2014
"It is with careful consideration and mutual respect that we have decided to end our marriage," the couple said in a statement. "Our primary concern remains the wellbeing of our children, and we ask with profound gratitude that you respect our family's privacy at this very sensitive time."
Dempsey, 49, and Fink are the parents of three children, 12-year-old Tallulah and 7-year-old twins Sullivan and Darby.
WATCH: Hollywood's Biggest Divorces
The actor was reportedly in Daytona Beach, Fla. for a racing event at the time of his wife’s divorce filing.
This would be Dempsey's second divorce. He was previously wed to actress Rochelle Parker from 1987 to 1994.
Dempsey is one of the highest-paid actors in TV, making a reported $16 million in 2014 from his Grey’s Anatomy stint and endorsement deals. Watch the video below for television's other top-paid actors.