PICS: Celebrity Career Comebacks

One-time child actress Mayim Bialik made numerous guest appearances in shows like "The Facts of Life" and "MacGuyver" before landing her big break on the NBC sitcom, "Blossom." After its final show, she was mainly doing voice-over work until her return to primetime on "The Big Bang Theory."

Winona Ryder was first a promising young actress in the 80s and 90s, appearing in 'Beetlejuice,' 'Edward Scissorhands' and 'Little Women.' All that came to a halt when she was arrested on shoplifting charges in 2001. After a lengthy hiatus, she's been back to work and in some prestigious films, having starred in Darren Aronofsky's 'Black Swan.'

The 'Robin Hood' star got his start in Australia in plays and small productions, which led to early success. Once he came to the United States, he noticed a considerable raise in popularity thanks to films like 'Gladiator' and 'A Beautiful Mind,' both of which garnered him Oscar nominations (he won with 'Gladiator').

Since his first American film 'Stand by Me,' Kiefer Sutherland was something of a journeyman, appearing in more than 70 films including 'Flatliners' and 'A Time to Kill.' He began to really reap the fruits of his labor once he took on the lead role in the critically acclaimed television series, "24."

Busting out in a big way with movies like 'Saturday Night Fever' and 'Grease,' John was poised to become the next big thing since sliced bread. Unfortunately, he was mired in a declining film career until he appeared in Quentin Tarentino's hit 'Pulp Fiction.' Since then, he's kept the success ball rolling.

Besides Oprah, Martha Stewart was virtually unstoppable as she had cookbooks flying off the shelves, her magazine and her own TV show, but that all came to a halt after she was convicted of conspiracy and securities fraud. Now the homemaker has returned to oversee her profitable ventures and her award-winning show.

The "Two and a Half Men" star hasn't always enjoyed success. Since coming onto the scene in the 80s and 90s with films like 'No Small Affair,' 'Pretty in Pink' and 'Hotshots,' Cryer went through a rough patch, having starred in quickly canceled sitcoms. Now with an Emmy by his side and on a hit comedy show, he's making the most of his second chance.

America's favorite pop star had her share of setbacks as she infamously shaved her head and was forced into a psychiatric ward in 2007. Now, she's enjoying motherhood and the success of her latest album, Femme Fatale.

"Doogie Houser, M.D." made him the next big thing and once the show was cancelled, it was almost as if he decided to retire prematurely. After a lengthy hiatus, Neil's cameos in 'Harold and Kumar Go to White Castle' brought him back into the spotlight and helped him in landing a role on the popular sitcom, "How I Met Your Mother."

The one-time pretty boy of Hollywood showed why he deserved that title in films like '9 ½ Weeks' and 'Angel Heart.' His sudden decision to go into professional boxing left him physically battered and helped land him into anonymity. Thanks to his Oscar-nominated role in Darren Aronofsky's 'The Wrestler,' Rourke has been enjoying the notoriety he willingly left decades ago.

One of Hollywood's loveable actors, the star did have his share of troubles when he left a threatening voicemail to his daughter back in 2007, which lead to a drop in offers. Now, the world gets to see a funnier side of Alec with his role on the hit sitcom "30 Rock."

The 'Iron Man' star didn't have it as plush prior to his blockbuster hit. He went through a bout with the law and drugs before resurrecting his career with the popular comic book film.

Everyone goes through lulls in their lives and careers, and if there's one thing people love more than a fall from grace (or obscurity), it's a triumphant return to the spotlight. Check out these celebrities who have revamped their images after unfortunate setbacks.